Mutant Huntingtin Expression in Clonal Striatal Cells: Dissociation of Inclusion Formation and Neuronal Survival by Caspase Inhibition

Neuronal intranuclear inclusions are found in the brains of patients with Huntington’s disease and form from the polyglutamine-expanded N-terminal region of mutant huntingtin. To explore the properties of inclusions and their involvement in cell death, mouse clonal striatal cells were transiently tr...

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Udgivet i:J Neurosci
Main Authors: Kim, Manho, Lee, H-S, LaForet, Genevieve, McIntyre, Charmian, Martin, Eileen J., Chang, Patrick, Kim, Tae Wan, Williams, M., Reddy, P. H., Tagle, Dan, Boyce, Frederick M., Won, Lisa, Heller, Alfred, Aronin, Neil, DiFiglia, Marian
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 1999
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782141/
https://ncbi.nlm.nih.gov/pubmed/9920660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-03-00964.1999
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