miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells

Clinically, one of the principal factors in the failure of advanced colorectal cancer (CRC) treatment is chemoresistance to 5-fluorouracil (5FU)-based chemotherapy. Although microRNA-375-3p (miR-375) is considered a tumor suppressor in multiple cancers, the mechanism of miR-375 in the regulation of...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Xu, Xueni, Chen, Xiaoxiang, Xu, Mu, Liu, Xiangxiang, Pan, Bei, Qin, Jian, Xu, Tao, Zeng, Kaixuan, Pan, Yuqin, He, Bangshun, Sun, Huiling, Sun, Li, Wang, Shukui
Format: Artigo
Language:Inglês
Published: Impact Journals 2019
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781994/
https://ncbi.nlm.nih.gov/pubmed/31543507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102214
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