Antiviral therapy may decrease HBx, affecting cccDNA and MSL2 in hepatocarcinogenesis

Chronic hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC). Covalently closed circular DNA (cccDNA) is an intermediate in the life cycle of HBV. HBV-encoded X protein (HBx), a key viral oncoprotein, can be specifically ubiquitylated by male specific lethal 2 (MSL2), which...

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Publicado no:Oncol Lett
Main Authors: Jin, Xue-Li, Hong, Suk Kyun, Kim, Hwajung, Lee, Sun-Kyung, Yi, Nam-Joon, Lee, Kwang-Woong, Suh, Kyung-Suk
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781749/
https://ncbi.nlm.nih.gov/pubmed/31612010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2019.10833
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