Akt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer

BACKGROUND: Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potentia...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Luan, Wenqing, Pang, Yingxin, Li, Rui, Wei, Xuan, Jiao, Xiaoxiao, Shi, Juanjuan, Yu, Jiangtao, Mao, Hongluan, Liu, Peishu
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781612/
https://ncbi.nlm.nih.gov/pubmed/31632060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S220267
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