Akt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer

BACKGROUND: Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potentia...

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Vydáno v:Onco Targets Ther
Hlavní autoři: Luan, Wenqing, Pang, Yingxin, Li, Rui, Wei, Xuan, Jiao, Xiaoxiao, Shi, Juanjuan, Yu, Jiangtao, Mao, Hongluan, Liu, Peishu
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2019
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781612/
https://ncbi.nlm.nih.gov/pubmed/31632060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S220267
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