Akt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer

BACKGROUND: Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potentia...

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Detalles Bibliográficos
Publicado en:Onco Targets Ther
Autores principales: Luan, Wenqing, Pang, Yingxin, Li, Rui, Wei, Xuan, Jiao, Xiaoxiao, Shi, Juanjuan, Yu, Jiangtao, Mao, Hongluan, Liu, Peishu
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove 2019
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781612/
https://ncbi.nlm.nih.gov/pubmed/31632060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S220267
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