Genome-wide allele-specific methylation is enriched at gene regulatory regions in a multi-generation pedigree from the Norfolk Island isolate

BACKGROUND: Allele-specific methylation (ASM) occurs when DNA methylation patterns exhibit asymmetry among alleles. ASM occurs at imprinted loci, but its presence elsewhere across the human genome is indicative of wider importance in terms of gene regulation and disease risk. Here, we studied ASM by...

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Bibliografski detalji
Izdano u:Epigenetics Chromatin
Glavni autori: Benton, Miles C., Lea, Rodney A., Macartney-Coxson, Donia, Sutherland, Heidi G., White, Nicole, Kennedy, Daniel, Mengersen, Kerry, Haupt, Larisa M., Griffiths, Lyn R.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781349/
https://ncbi.nlm.nih.gov/pubmed/31594537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0304-7
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