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Genome-wide allele-specific methylation is enriched at gene regulatory regions in a multi-generation pedigree from the Norfolk Island isolate

BACKGROUND: Allele-specific methylation (ASM) occurs when DNA methylation patterns exhibit asymmetry among alleles. ASM occurs at imprinted loci, but its presence elsewhere across the human genome is indicative of wider importance in terms of gene regulation and disease risk. Here, we studied ASM by...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Benton, Miles C., Lea, Rodney A., Macartney-Coxson, Donia, Sutherland, Heidi G., White, Nicole, Kennedy, Daniel, Mengersen, Kerry, Haupt, Larisa M., Griffiths, Lyn R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781349/
https://ncbi.nlm.nih.gov/pubmed/31594537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0304-7
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