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RRAS2 shapes the TCR repertoire by setting the threshold for negative selection
Signal strength controls the outcome of αβ T cell selection in the thymus, resulting in death if the affinity of the rearranged TCR is below the threshold for positive selection, or if the affinity of the TCR is above the threshold for negative selection. Here we show that deletion of the GTPase RRA...
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| Pubblicato in: | J Exp Med |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Rockefeller University Press
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6781009/ https://ncbi.nlm.nih.gov/pubmed/31324740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181959 |
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