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Is Alzheimer disease a failure of mobilizing immune defense? Lessons from cognitively fit oldest-old

Multifaceted evidence supports the hypothesis that inflammatory-immune mechanisms contribute to Alzheimer disease (AD) neuropathology and genetic association of several immune specific genes (TREM2, CR1, and CD33) suggests that maladaptive immune responses may be pivotal drivers of AD pathogenesis....

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Bibliografske podrobnosti
izdano v:Dialogues Clin Neurosci
Main Authors: Katsel, Pavel, Haroutunian, Vahram
Format: Artigo
Jezik:Inglês
Izdano: Les Laboratoires Servier 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780355/
https://ncbi.nlm.nih.gov/pubmed/31607776
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