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Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection

BACKGROUND AND PURPOSE: Severe influenza A virus (IAV) infections are associated with damaging hyperinflammation that can be fatal. There is an urgent need to identify new therapeutic agents to treat severe and pathogenic IAV infections. Repurposing of drugs with an existing and studied pharmacokine...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Rosli, Sarah, Kirby, Francis J., Lawlor, Kate E., Rainczuk, Kate, Drummond, Grant R., Mansell, Ashley, Tate, Michelle D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780046/
https://ncbi.nlm.nih.gov/pubmed/31271646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14787
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