Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1

Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones negatively regulate the activity of Hsf1 via stress-responsive mechanisms that are poorly understood. Here, we have reconsti...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Masser, Anna E, Kang, Wenjing, Roy, Joydeep, Mohanakrishnan Kaimal, Jayasankar, Quintana-Cordero, Jany, Friedländer, Marc R, Andréasson, Claes
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2019
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779467/
https://ncbi.nlm.nih.gov/pubmed/31552827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47791
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