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Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1
Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones negatively regulate the activity of Hsf1 via stress-responsive mechanisms that are poorly understood. Here, we have reconsti...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6779467/ https://ncbi.nlm.nih.gov/pubmed/31552827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47791 |
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