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Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae

Protein aggregation is intimately associated with cellular stress and is accelerated during aging, disease, and cellular dysfunction. Yeast cells rely on the ATP-consuming chaperone Hsp104 to disaggregate proteins together with Hsp70. Hsp110s are ancient and abundant chaperones that form complexes w...

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Библиографические подробности
Опубликовано в: :Mol Cell Biol
Главные авторы: Kaimal, Jayasankar Mohanakrishnan, Kandasamy, Ganapathi, Gasser, Fabian, Andréasson, Claes
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440654/
https://ncbi.nlm.nih.gov/pubmed/28289075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00027-17
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