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Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae

Protein aggregation is intimately associated with cellular stress and is accelerated during aging, disease, and cellular dysfunction. Yeast cells rely on the ATP-consuming chaperone Hsp104 to disaggregate proteins together with Hsp70. Hsp110s are ancient and abundant chaperones that form complexes w...

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Publicado en:Mol Cell Biol
Main Authors: Kaimal, Jayasankar Mohanakrishnan, Kandasamy, Ganapathi, Gasser, Fabian, Andréasson, Claes
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440654/
https://ncbi.nlm.nih.gov/pubmed/28289075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00027-17
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