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Cytosolic splice isoform of Hsp70 nucleotide exchange factor Fes1 is required for the degradation of misfolded proteins in yeast

Cells maintain proteostasis by selectively recognizing and targeting misfolded proteins for degradation. In Saccharomyces cerevisiae, the Hsp70 nucleotide exchange factor Fes1 is essential for the degradation of chaperone-associated misfolded proteins by the ubiquitin-proteasome system. Here we show...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Gowda, Naveen Kumar Chandappa, Kaimal, Jayasankar Mohanakrishnan, Masser, Anna E., Kang, Wenjing, Friedländer, Marc R., Andréasson, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831876/
https://ncbi.nlm.nih.gov/pubmed/26912797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-10-0697
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