Glomerular Immunodeposits of Patients with IgA Nephropathy Are Enriched for IgG Autoantibodies Specific for Galactose-Deficient IgA1

BACKGROUND: IgA nephropathy (IgAN) is the leading primary GN worldwide. The disease is thought to result from glomerular deposition of circulating immune complexes of IgG bound to galactose-deficient IgA1 (Gd-IgA1). However, routine immunofluorescence microscopy fails to detect IgG in many kidney bi...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Rizk, Dana V., Saha, Manish K., Hall, Stacy, Novak, Lea, Brown, Rhubell, Huang, Zhi-Qiang, Fatima, Huma, Julian, Bruce A., Novak, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779349/
https://ncbi.nlm.nih.gov/pubmed/31444275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018111156
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