Prenatal Testosterone Exposure Alters GABAergic Synaptic Inputs to GnRH and KNDy Neurons in a Sheep Model of Polycystic Ovarian Syndrome

Prenatal testosterone (T)-treated female sheep display reproductive deficits similar to women with polycystic ovarian syndrome (PCOS), including an increase in LH pulse frequency due to actions of the central GnRH pulse generator. In this study, we used multiple-label immunocytochemistry to investig...

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發表在:Endocrinology
Main Authors: Porter, Danielle T, Moore, Aleisha M, Cobern, Jade A, Padmanabhan, Vasantha, Goodman, Robert L, Coolen, Lique M, Lehman, Michael N
格式: Artigo
語言:Inglês
出版: Endocrine Society 2019
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779074/
https://ncbi.nlm.nih.gov/pubmed/31415088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00137
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