Prenatal Testosterone Exposure Alters GABAergic Synaptic Inputs to GnRH and KNDy Neurons in a Sheep Model of Polycystic Ovarian Syndrome

Prenatal testosterone (T)-treated female sheep display reproductive deficits similar to women with polycystic ovarian syndrome (PCOS), including an increase in LH pulse frequency due to actions of the central GnRH pulse generator. In this study, we used multiple-label immunocytochemistry to investig...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Porter, Danielle T, Moore, Aleisha M, Cobern, Jade A, Padmanabhan, Vasantha, Goodman, Robert L, Coolen, Lique M, Lehman, Michael N
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779074/
https://ncbi.nlm.nih.gov/pubmed/31415088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00137
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