Prenatal Testosterone Treatment Leads to Changes in the Morphology of KNDy Neurons, Their Inputs, and Projections to GnRH Cells in Female Sheep

Prenatal testosterone (T)-treated ewes display a constellation of reproductive defects that closely mirror those seen in PCOS women, including altered hormonal feedback control of GnRH. Kisspeptin/neurokinin B/dynorphin (KNDy) neurons of the arcuate nucleus (ARC) play a key role in steroid feedback...

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Publicado en:Endocrinology
Autores principales: Cernea, Maria, Padmanabhan, Vasantha, Goodman, Robert L., Coolen, Lique M., Lehman, Michael N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541615/
https://ncbi.nlm.nih.gov/pubmed/26061725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1609
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