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In vitro aged, hiPSC-origin engineered heart tissue models with age-dependent functional deterioration to study myocardial infarction

Deaths attributed to ischemic heart disease increased by 41.7% from 1990 to 2013. This is primarily due to an increase in the aged population, however, research on cardiovascular disease (CVD) has been overlooking aging, a well-documented contributor to CVD. The use of young animals is heavily prefe...

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Detalhes bibliográficos
Publicado no:Acta Biomater
Main Authors: Acun, Aylin, Nguyen, Trung Dung, Zorlutuna, Pinar
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779061/
https://ncbi.nlm.nih.gov/pubmed/31146032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2019.05.064
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