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Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics

Neuropsychiatric disorders are highly heritable polygenic disorders arising from the complex interplay of highly penetrant rare variants and common variants of small effect. There is a large index of comorbidity and shared genetic risk between disorders, reflecting the pleiotropy of individual varia...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell Neurosci
Hoofdauteurs: Matos, Marliette R., Ho, Seok-Man, Schrode, Nadine, Brennand, Kristen J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484226/
https://ncbi.nlm.nih.gov/pubmed/32712198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2020.103532
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