Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and function

BACKGROUND: Oxidative stress and vascular smooth muscle cell (VSMC) phenotypic modulation influence intracranial aneurysm (IA) formation and progression. Oxidative stress plays an important role in phenotype switching, and nuclear factor erythroid 2-related factor 2 (Nrf-2) is one of the main antiox...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Shi, Yuan, Li, Sichen, Song, Yaying, Liu, Peixi, Yang, Zixiao, Liu, Yingjun, Quan, Kai, Yu, Guo, Fan, Zhiyuan, Zhu, Wei
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778377/
https://ncbi.nlm.nih.gov/pubmed/31585542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1568-3
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