Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway

BACKGROUND: The regulation of vascular smooth muscle cell (VSMC) phenotype plays an important role in intracranial aneurysm (IA) formation and progression. However, the underlying mechanism remains unclear. Metformin is a 5′ AMP-activated protein kinase (AMPK) agonist that has a protective effect on...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Li, Sichen, Shi, Yuan, Liu, Peixi, Song, Yaying, Liu, Yingjun, Ying, Lingwen, Quan, Kai, Yu, Guo, Fan, Zhiyuan, Zhu, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298751/
https://ncbi.nlm.nih.gov/pubmed/32546267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01868-4
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