Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway

BACKGROUND: The regulation of vascular smooth muscle cell (VSMC) phenotype plays an important role in intracranial aneurysm (IA) formation and progression. However, the underlying mechanism remains unclear. Metformin is a 5′ AMP-activated protein kinase (AMPK) agonist that has a protective effect on...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Li, Sichen, Shi, Yuan, Liu, Peixi, Song, Yaying, Liu, Yingjun, Ying, Lingwen, Quan, Kai, Yu, Guo, Fan, Zhiyuan, Zhu, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298751/
https://ncbi.nlm.nih.gov/pubmed/32546267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01868-4
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge