N6-methyladenosine modification controls circular RNA immunity

Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self vs. foreign identity in circRNA immunity is unknown. Here we show that N6-methyladenosine (m(6)A) RNA modification on huma...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Chen, Y. Grace, Chen, Robert, Ahmad, Sadeem, Verma, Rohit, Kasturi, Sudhir, Amaya, Laura, Broughton, James P., Kim, Jeewon, Cadena, Cristhian, Pulendran, Bali, Hur, Sun, Chang, Howard Y.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778039/
https://ncbi.nlm.nih.gov/pubmed/31474572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.016
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