N6-methyladenosine modification controls circular RNA immunity

Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self vs. foreign identity in circRNA immunity is unknown. Here we show that N6-methyladenosine (m(6)A) RNA modification on huma...

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Pubblicato in:Mol Cell
Autori principali: Chen, Y. Grace, Chen, Robert, Ahmad, Sadeem, Verma, Rohit, Kasturi, Sudhir, Amaya, Laura, Broughton, James P., Kim, Jeewon, Cadena, Cristhian, Pulendran, Bali, Hur, Sun, Chang, Howard Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778039/
https://ncbi.nlm.nih.gov/pubmed/31474572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.016
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