A G protein–coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23

Dysregulated actions of bone-derived phosphaturic hormone fibroblast growth factor 23 (FGF23) result in several inherited diseases, such as X-linked hypophosphatemia (XLH), and contribute substantially to the mortality in kidney failure. Mechanisms governing FGF23 production are poorly defined. We h...

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Pubblicato in:JCI Insight
Autori principali: He, Qing, Shumate, Lauren T., Matthias, Julia, Aydin, Cumhur, Wein, Marc N., Spatz, Jordan M., Goetz, Regina, Mohammadi, Moosa, Plagge, Antonius, Divieti Pajevic, Paola, Bastepe, Murat
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777913/
https://ncbi.nlm.nih.gov/pubmed/31484825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125007
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