Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) requires mitochondrial oxidative phosphorylation (OXPHOS) to fuel its growth; however, broadly inhibiting this pathway might also disrupt essential mitochondrial functions in normal tissues. PDAC cells exhibit abnormally fragmented mitochondria that are essent...

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Publicado en:JCI Insight
Main Authors: Yu, Meifang, Nguyen, Nicholas D., Huang, Yanqing, Lin, Daniel, Fujimoto, Tara N., Molkentine, Jessica M., Deorukhkar, Amit, Kang, Ya’an, San Lucas, F. Anthony, Fernandes, Conrad J., Koay, Eugene J., Gupta, Sonal, Ying, Haoqiang, Koong, Albert C., Herman, Joseph M., Fleming, Jason B., Maitra, Anirban, Taniguchi, Cullen M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777817/
https://ncbi.nlm.nih.gov/pubmed/31335325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126915
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