Antisense oligonucleotides extend survival of prion-infected mice

Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals caused by conversion of cellular prion protein (PrP(C)) into a self-propagating neurotoxic conformer (prions; PrP(Sc)). Strong genetic proofs of concept support lowering PrP expression as a therapeutic strategy...

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Publicado en:JCI Insight
Main Authors: Raymond, Gregory J., Zhao, Hien Tran, Race, Brent, Raymond, Lynne D., Williams, Katie, Swayze, Eric E., Graffam, Samantha, Le, Jason, Caron, Tyler, Stathopoulos, Jacquelyn, O’Keefe, Rhonda, Lubke, Lori L., Reidenbach, Andrew G., Kraus, Allison, Schreiber, Stuart L., Mazur, Curt, Cabin, Deborah E., Carroll, Jeffrey B., Minikel, Eric Vallabh, Kordasiewicz, Holly, Caughey, Byron, Vallabh, Sonia M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777807/
https://ncbi.nlm.nih.gov/pubmed/31361599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131175
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