Opportunities and challenges for transcriptome-wide association studies

Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to identify gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes at GWAS loci, by using simulations an...

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Gepubliceerd in:Nat Genet
Hoofdauteurs: Wainberg, Michael, Sinnott-Armstrong, Nasa, Mancuso, Nicholas, Barbeira, Alvaro N., Knowles, David A., Golan, David, Ermel, Raili, Ruusalepp, Arno, Quertermous, Thomas, Hao, Ke, Björkegren, Johan L. M., Kyung Im, Hae, Pasaniuc, Bogdan, Rivas, Manuel A., Kundaje, Anshul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777347/
https://ncbi.nlm.nih.gov/pubmed/30926968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0385-z
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