Opportunities and challenges for transcriptome-wide association studies

Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to identify gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes at GWAS loci, by using simulations an...

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Detaylı Bibliyografya
Yayımlandı:Nat Genet
Asıl Yazarlar: Wainberg, Michael, Sinnott-Armstrong, Nasa, Mancuso, Nicholas, Barbeira, Alvaro N., Knowles, David A., Golan, David, Ermel, Raili, Ruusalepp, Arno, Quertermous, Thomas, Hao, Ke, Björkegren, Johan L. M., Kyung Im, Hae, Pasaniuc, Bogdan, Rivas, Manuel A., Kundaje, Anshul
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777347/
https://ncbi.nlm.nih.gov/pubmed/30926968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0385-z
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