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Structural Perturbations due to Mutation (H1047R) in Phosphoinositide-3-kinase (PI3Kα) and Its Involvement in Oncogenesis: An in Silico Insight
[Image: see text] PI3Kα is a heterodimer protein consisting of two subunits (p110α and p85α) which promotes various signaling pathways. Oncogenic mutation in the catalytic subunit p110α of PI3Kα at the 1047 position in the kinase domain substitutes the histidine with arginine. This mutation brings a...
Enregistré dans:
| Publié dans: | ACS Omega |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2019
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6776984/ https://ncbi.nlm.nih.gov/pubmed/31592171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01439 |
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