CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling

Cyclin‐dependent kinase 12 (CDK12) has emerged as an effective therapeutic target due to its ability to regulate DNA damage repair in human cancers, but little is known about the role of CDK12 in driving tumorigenesis. Here, we demonstrate that CDK12 promotes tumor initiation as a novel regulator of...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Choi, Hee‐Joo, Jin, Sora, Cho, Hani, Won, Hee‐Young, An, Hee Woon, Jeong, Ga‐Young, Park, Young‐Un, Kim, Hyung‐Yong, Park, Mi Kyung, Son, Taekwon, Min, Kyueng‐Whan, Jang, Ki‐Seok, Oh, Young‐Ha, Lee, Jeong‐Yeon, Kong, Gu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776914/
https://ncbi.nlm.nih.gov/pubmed/31468695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948058
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