CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling

Cyclin‐dependent kinase 12 (CDK12) has emerged as an effective therapeutic target due to its ability to regulate DNA damage repair in human cancers, but little is known about the role of CDK12 in driving tumorigenesis. Here, we demonstrate that CDK12 promotes tumor initiation as a novel regulator of...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:EMBO Rep
Asıl Yazarlar: Choi, Hee‐Joo, Jin, Sora, Cho, Hani, Won, Hee‐Young, An, Hee Woon, Jeong, Ga‐Young, Park, Young‐Un, Kim, Hyung‐Yong, Park, Mi Kyung, Son, Taekwon, Min, Kyueng‐Whan, Jang, Ki‐Seok, Oh, Young‐Ha, Lee, Jeong‐Yeon, Kong, Gu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776914/
https://ncbi.nlm.nih.gov/pubmed/31468695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948058
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller