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TDP2 negatively regulates axon regeneration by inducing SUMOylation of an Ets transcription factor

In Caenorhabditis elegans, the JNK MAP kinase (MAPK) pathway is important for axon regeneration. The JNK pathway is activated by a signaling cascade consisting of the growth factor SVH‐1 and its receptor tyrosine kinase SVH‐2. Expression of the svh‐2 gene is induced by axonal injury in a process inv...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Sakai, Yoshiki, Hanafusa, Hiroshi, Pastuhov, Strahil Iv, Shimizu, Tatsuhiro, Li, Chun, Hisamoto, Naoki, Matsumoto, Kunihiro
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776894/
https://ncbi.nlm.nih.gov/pubmed/31393064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847517
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