A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases

The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 e...

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Publicado en:Nat Commun
Autores principales: Kiss, Leo, Zeng, Jingwei, Dickson, Claire F., Mallery, Donna L., Yang, Ji-Chun, McLaughlin, Stephen H., Boland, Andreas, Neuhaus, David, James, Leo C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776665/
https://ncbi.nlm.nih.gov/pubmed/31582740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12388-y
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