Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

Mechanisms of muscle atrophy are complex and their understanding might help finding therapeutic solutions for pathologies such as amyotrophic lateral sclerosis (ALS). We meta-analyzed transcriptomic experiments of muscles of ALS patients and mouse models, uncovering a p53 deregulation as common deno...

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Pubblicato in:eLife
Autori principali: von Grabowiecki, Yannick, Abreu, Paula, Blanchard, Orphee, Palamiuc, Lavinia, Benosman, Samir, Mériaux, Sophie, Devignot, Véronique, Gross, Isabelle, Mellitzer, Georg, Gonzalez de Aguilar, José L, Gaiddon, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786414/
https://ncbi.nlm.nih.gov/pubmed/26919175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10528
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