Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

Mechanisms of muscle atrophy are complex and their understanding might help finding therapeutic solutions for pathologies such as amyotrophic lateral sclerosis (ALS). We meta-analyzed transcriptomic experiments of muscles of ALS patients and mouse models, uncovering a p53 deregulation as common deno...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: von Grabowiecki, Yannick, Abreu, Paula, Blanchard, Orphee, Palamiuc, Lavinia, Benosman, Samir, Mériaux, Sophie, Devignot, Véronique, Gross, Isabelle, Mellitzer, Georg, Gonzalez de Aguilar, José L, Gaiddon, Christian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2016
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786414/
https://ncbi.nlm.nih.gov/pubmed/26919175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10528
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak