CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis

The molecular mechanism of intervertebral disc degeneration (IVDD) remains unclear. This study aimed to investigate the role of circular RNAs (circRNAs) in the pathogenesis of IVDD. We sued nucleus pulposus (NP) tissues of patients, tert-butyl hydroperoxide (TBHP) stimulated NP cells (NPCs), and IVD...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Xie, Lin, Huang, Weibo, Fang, Zhenhua, Ding, Fan, Zou, Fei, Ma, Xiaosheng, Tao, Jie, Guo, Jingkang, Xia, Xinlei, Wang, Hongli, Yu, Zuochong, Lu, Feizhou, Jiang, Jianyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776655/
https://ncbi.nlm.nih.gov/pubmed/31582722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1978-2
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