The Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer—The Impact in Intratumoral Heterogeneity

Purpose: Intratumoral genetic heterogeneity (ITGH) is a common feature of solid tumors. However, little is known about the effect of neoadjuvant chemoradiation (nCRT) in ITGH of rectal tumors that exhibit poor response to nCRT. Here, we examined the impact of nCRT in the mutational profile and ITGH...

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Veröffentlicht in:Front Oncol
Hauptverfasser: Bettoni, Fabiana, Masotti, Cibele, Corrêa, Bruna R., Donnard, Elisa, dos Santos, Filipe F., São Julião, Guilherme P., Vailati, Bruna B., Habr-Gama, Angelita, Galante, Pedro A. F., Perez, Rodrigo O., Camargo, Anamaria A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776613/
https://ncbi.nlm.nih.gov/pubmed/31612112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00974
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