The Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer—The Impact in Intratumoral Heterogeneity

Purpose: Intratumoral genetic heterogeneity (ITGH) is a common feature of solid tumors. However, little is known about the effect of neoadjuvant chemoradiation (nCRT) in ITGH of rectal tumors that exhibit poor response to nCRT. Here, we examined the impact of nCRT in the mutational profile and ITGH...

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Bibliografski detalji
Izdano u:Front Oncol
Glavni autori: Bettoni, Fabiana, Masotti, Cibele, Corrêa, Bruna R., Donnard, Elisa, dos Santos, Filipe F., São Julião, Guilherme P., Vailati, Bruna B., Habr-Gama, Angelita, Galante, Pedro A. F., Perez, Rodrigo O., Camargo, Anamaria A.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Oncology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776613/
https://ncbi.nlm.nih.gov/pubmed/31612112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00974
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