Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice

Back pain is a leading cause of global disability and is strongly associated with intervertebral disc (IVD) degeneration (IDD). Hallmarks of IDD include progressive cell loss and matrix degradation. The Akt signaling pathway regulates cellularity and matrix production in IVDs and its inactivation is...

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Publicado no:Cell Death Dis
Main Authors: Zhang, Changli, Smith, Madeline P., Zhou, George K., Lai, Alon, Hoy, Robert C., Mroz, Victoria, Torre, Olivia M., Laudier, Damien M., Bradley, Elizabeth W., Westendorf, Jennifer J., Iatridis, James C., Illien-Jünger, Svenja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776553/
https://ncbi.nlm.nih.gov/pubmed/31582730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1985-3
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