Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation

LRRC7 has been identified as a candidate gene for severe childhood emotional dysregulation. Direct experimental evidence for a role of LRRC7 in the disease is needed, as is a better understanding of its impact on neuronal structure and signaling, and hence potential treatment targets. Here, we gener...

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Bibliografiset tiedot
Julkaisussa:Transl Psychiatry
Päätekijät: Chong, Chi Ho, Li, Qi, Mak, Priscilla Hoi Shan, Ng, Cypress Chun Pong, Leung, Eva Hin Wa, Tan, Vicky Huiqi, Chan, Anthony Kin Wang, McAlonan, Grainne, Chan, Siu Yuen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776540/
https://ncbi.nlm.nih.gov/pubmed/31582721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-019-0580-9
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