Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes

Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes. Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to PDN in patients and pain-like behavior in rodent models of type 1 and type 2 diabetes. Here, we addressed the MG-related...

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Détails bibliographiques
Publié dans:Neurobiol Dis
Auteurs principaux: Griggs, Ryan B., Santos, Diogo F., Laird, Don E., Doolen, Suzanne, Donahue, Renee R., Wessel, Caitlin R., Fu, Weisi, Sinha, Ghanshyam P., Wang, Pingyuan, Zhou, Jia, Brings, Sebastian, Fleming, Thomas, Nawroth, Peter P., Susuki, Keiichiro, Taylor, Bradley K.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776480/
https://ncbi.nlm.nih.gov/pubmed/30807826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.02.019
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