Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes

Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes. Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to PDN in patients and pain-like behavior in rodent models of type 1 and type 2 diabetes. Here, we addressed the MG-related...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Griggs, Ryan B., Santos, Diogo F., Laird, Don E., Doolen, Suzanne, Donahue, Renee R., Wessel, Caitlin R., Fu, Weisi, Sinha, Ghanshyam P., Wang, Pingyuan, Zhou, Jia, Brings, Sebastian, Fleming, Thomas, Nawroth, Peter P., Susuki, Keiichiro, Taylor, Bradley K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776480/
https://ncbi.nlm.nih.gov/pubmed/30807826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.02.019
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