Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of Cysteine

[Image: see text] The prenylation of peptides and proteins is an important post-translational modification observed in vivo. We report that the Pd-catalyzed Tsuji–Trost allylation with a Pd/BIPHEPHOS catalyst system allows the allylation of Cys-containing peptides and proteins with complete chemosel...

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Udgivet i:J Am Chem Soc
Main Authors: Schlatzer, Thomas, Kriegesmann, Julia, Schröder, Hilmar, Trobe, Melanie, Lembacher-Fadum, Christian, Santner, Simone, Kravchuk, Alexander V., Becker, Christian F. W., Breinbauer, Rolf
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776382/
https://ncbi.nlm.nih.gov/pubmed/31469558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b08279
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