Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury

Cognitive impairments are a common consequence of traumatic brain injury (TBI). The hippocampus is a subcortical structure that plays a key role in the formation of declarative memories and is highly vulnerable to TBI. The α7 nicotinic acetylcholine receptor (nAChR) is highly expressed in the hippoc...

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Pubblicato in:PLoS One
Autori principali: Titus, David J., Johnstone, Timothy, Johnson, Nathan H., London, Sidney H., Chapalamadugu, Meghana, Hogenkamp, Derk, Gee, Kelvin W., Atkins, Coleen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776323/
https://ncbi.nlm.nih.gov/pubmed/31581202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223180
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