Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose beads for the comprehensive enrichment of endogenously expressed protein kinases from cell lines and tissues. These beads enable chemoproteomics profiling of kinase inhibitors of interest in dose-dependent competition stud...

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Publicado en:Sci Rep
Main Authors: Eberl, H. Christian, Werner, Thilo, Reinhard, Friedrich B., Lehmann, Stephanie, Thomson, Douglas, Chen, Peiling, Zhang, Cunyu, Rau, Christina, Muelbaier, Marcel, Drewes, Gerard, Drewry, David, Bantscheff, Marcus
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775116/
https://ncbi.nlm.nih.gov/pubmed/31578349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50335-5
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