Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose beads for the comprehensive enrichment of endogenously expressed protein kinases from cell lines and tissues. These beads enable chemoproteomics profiling of kinase inhibitors of interest in dose-dependent competition stud...

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Udgivet i:Sci Rep
Main Authors: Eberl, H. Christian, Werner, Thilo, Reinhard, Friedrich B., Lehmann, Stephanie, Thomson, Douglas, Chen, Peiling, Zhang, Cunyu, Rau, Christina, Muelbaier, Marcel, Drewes, Gerard, Drewry, David, Bantscheff, Marcus
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775116/
https://ncbi.nlm.nih.gov/pubmed/31578349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50335-5
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