Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

[Image: see text] The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness, and there is an urgent unmet need for improved treatments. Parasite protein kinases are attractive drug targets, provided that the host and parasite kinomes are sufficiently divergent to...

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Main Authors: Urbaniak, Michael D., Mathieson, Toby, Bantscheff, Marcus, Eberhard, Dirk, Grimaldi, Raffaella, Miranda-Saavedra, Diego, Wyatt, Paul, Ferguson, Michael A. J., Frearson, Julie, Drewes, Gerard
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621575/
https://ncbi.nlm.nih.gov/pubmed/22908928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300326z
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