IMMUNOPATHOLOGIC STRATIFICATION OF COLORECTAL CANCER FOR CHECKPOINT BLOCKADE IMMUNOTHERAPY

Mismatch-repair deficiency in solid tumors predict their response to PD-1 blockade. Based on this principle, pembrolizumab is approved as standard of care for patients with unresectable or metastatic microsatellite instability–high (MSI-H) cancer. Despite this success, a large majority of metastatic...

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Vydáno v:Cancer Immunol Res
Hlavní autoři: Llosa, Nicolas J., Luber, Brandon, Siegel, Nicholas, Awan, Anas H., Oke, Teniola, Zhu, Qingfeng, Barlett, Bjarne R., Aulakh, Laveet K., Thompson, Elizabeth D., Jaffee, Elizabeth M, Durham, Jennifer N., Sears, Cynthia L, Le, Dung T, Diaz, Luis A., Pardoll, Drew M., Wang, Hao, Housseau, Franck, Anders, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774859/
https://ncbi.nlm.nih.gov/pubmed/31439614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0927
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