IMMUNOPATHOLOGIC STRATIFICATION OF COLORECTAL CANCER FOR CHECKPOINT BLOCKADE IMMUNOTHERAPY

Mismatch-repair deficiency in solid tumors predict their response to PD-1 blockade. Based on this principle, pembrolizumab is approved as standard of care for patients with unresectable or metastatic microsatellite instability–high (MSI-H) cancer. Despite this success, a large majority of metastatic...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Llosa, Nicolas J., Luber, Brandon, Siegel, Nicholas, Awan, Anas H., Oke, Teniola, Zhu, Qingfeng, Barlett, Bjarne R., Aulakh, Laveet K., Thompson, Elizabeth D., Jaffee, Elizabeth M, Durham, Jennifer N., Sears, Cynthia L, Le, Dung T, Diaz, Luis A., Pardoll, Drew M., Wang, Hao, Housseau, Franck, Anders, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774859/
https://ncbi.nlm.nih.gov/pubmed/31439614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0927
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