INTRATUMORAL ADAPTIVE IMMUNOSUPPRESSION AND TYPE 17 IMMUNITY IN MISMATCH REPAIR PROFICIENT COLORECTAL TUMORS

PURPOSE: Approximately 10% of mismatch repair proficient (MMRp) colorectal cancer (CRC) patients showed clinical benefit to anti-PD-1 monotherapy (). We sought to identify biomarkers that delineate patients with immunoreactive CRC and to explore new combinatorial immunotherapy strategies that can im...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Llosa, Nicolas J., Luber, Brandon, Tam, Ada J., Smith, Kellie N., Siegel, Nicholas, Awan, Anas H., Fan, Hongni, Oke, Teniola, Zhang, JiaJia, Domingue, Jada, Engle, Elizabeth L., Roberts, Charles A., Bartlett, Bjarne R., Aulakh, Laveet K., Thompson, Elizabeth D., Taube, Janis M., Durham, Jennifer N., Sears, Cynthia L, Le, Dung T, Diaz, Luis A., Pardoll, Drew M., Wang, Hao, Anders, Robert A., Housseau, Franck
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726531/
https://ncbi.nlm.nih.gov/pubmed/31061070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0114
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