Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

The physiological role of leptin is thought to be a driving force to reduce food intake and increase energy expenditure. However, leptin therapies in the clinic have failed to effectively treat obesity, predominantly due to a phenomenon referred to as leptin resistance. The mechanisms linking obesit...

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Pubblicato in:Cell Metab
Autori principali: Zhao, Shangang, Zhu, Yi, Schultz, Robbie D., Li, Na, He, Zhenyan, Zhang, Zhuzhen, Caron, Alexandre, Zhu, Qingzhang, Sun, Kai, Xiong, Wei, Deng, Hui, Sun, Jia, Deng, Yingfeng, Kim, Min, Lee, Charlotte E., Gordillo, Ruth, Liu, Tiemin, Odle, Angela K., Childs, Gwen V., Zhang, Ningyan, Kusminski, Christine M., Elmquist, Joel K., Williams, Kevin W., An, Zhiqiang, Scherer, Philipp E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774814/
https://ncbi.nlm.nih.gov/pubmed/31495688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.08.005
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